How does CBD help with seizures?
Seizures are irregular misfirings of the electrical impulses in your brain, whether it’s due to trauma, a virus, or a hormonal imbalance. Of course, there are plenty of antiepileptic medications on the market today, but the problem with a lot of them is that they can be relatively ineffective in stopping the seizures and can also come with a whole host of negative side effects.
So how can CBD help? CBD being the non-psychoactive brother to THC triggers your body to release natural cannabinoids which then bind to the CB1 and CB2 receptors in your brain which in turn affect how nerves in your brain send signals.
So what do the studies find?
A study published in 2015 recorded data from 10 epilepsy enters with 213 patients (mean age 10.8) with various forms of epilepsy including DS and LGS syndromes, Aicardi syndrome, and Doose syndrome. In the study, the patients were given 200-300 mg of CBD a day. After a 12 week period, the patients showed seizure reduction at around 50%. The conclusion of this study was as follows: “These studies suggest that CBD avoids the psychoactive effects of the endocannabinoid system to provide a well-tolerated, promising therapeutic for the treatment of seizures, while whole-plant cannabis can both contribute to and reduce seizures”.
Another study published in 2017 recorded data from 23 epilepsy centers in the USA and Europe with 120 patients (mean age 9.8) with Dravet syndrome. In the study, the patients were given 20 mg of CBD a day in two doses. After 14 weeks and a 2 week titration period, the patients showed a median monthly seizure reduction frequency of 50% with median seizure reduction percentages ranging from 37% to 44%. The conclusion to this study was as follows: “In these studies, CBD was found to be superior to placebo in reducing the frequency of convulsive (tonic-clonic, tonic, clonic, and atonic) seizures in patients with Dravet syndrome, and the frequency of drop seizures in patients with Lennox-Gastaut syndrome. For the first time, there is now class 1 evidence that adjunctive use of CBD improves seizure control in patients with specific epilepsy syndromes.”