Anandamide and CBD: How Cannabidiol Effects and Enhances the Bliss Molecule
CBD and ‘Human THC’
Anandamide has gone by many nicknames since it’s initial discovery by Czech analytical scientist Lumir Hanus in March of ’92 who named it in homage to the Sanskrit word for ‘joy’. Sometimes called ‘the bliss molecule’ or ‘human THC’, Anandamide is an endogenous cannabinoid, meaning our body produces the cannabis component itself, as opposed to exogenous, or external cannabinoids, such as CBD or THC. Exogenous cannabinoids have shown profound effects on those of endogenous origin. A particularly beneficial example of this is the relationship between Anandamide and CBD, also known by it’s full name Cannabidiol and commonly harvested from the hemp plant. Below, we’ll further explore just what Anandamide is and how CBD hemp oil can enhance the advantages of this indigenous cannabinoid.
What is Anandamide?
A neurotransmitter capable of binding with both the CB1 and CB2 receptors, Anandamide is known for it’s mood enhancing abilities. Aside from being created internally, Anandamide is also found in the Cacao plant, which is used to make chocolate, and black truffles. We produce Anandamide in order for the body to maintain homeostasis, the process of keeping multiple imperative functions in the body in balance.
Anandamide aids with homeostasis through a process called neurogenesis which produces new nerve cells in the brain by binding to CB receptors. In research by esteemed chemist Dr. Raphael Mechoulam, it was determined that Anandamide is an endogenous analogue of THC, or is the body’s comparable inbred cannabinoid. Both agonists of the CB1 receptor, the main difference in the two cannabinoids is potency. THC is much more potent than Anandamide and Anandamide is much more molecular fragile than THC. This means that THC takes much longer to degrade than Anandamide and the effects of the indigenous cannabinoid don’t continue for nearly as long as that of THC.
How Does CBD Influence Anandamide?
The reason for Anandamide’s molecular fragility is due to the body’s production of the cannabinoid on demand as needed to aid in neurogenesis and other aspects of homeostasis, and then the fast-acting breakdown of the Anandamide by enzymes like fatty acid amide hydrolase (FAAH) and monoacylglycerol lipase (MAGL). CBD works to inhibit FAAH and similar enzymes keeping Anandamide active for longer, resulting in more thorough benefits. Through this advantageous relationship, CBD and Anandamide conjoin to offer a myriad of benefits that have become signature health and wellness influences of both cannabinoids.
The Benefits of Anandamide and CBD
● Helping to Relieve Depression and Anxiety– CBD has become renowned for aiding in relieving symptoms of various cognitive and emotional conditions and CBD products for anxiety are among the most popular use of the cannabinoid. Some research has pointed to CBD’s blocking of Anandamide hydrolysis, or chemical breakdown, and higher levels of Anandamide overall, promoted by Cannabidiol’s support, as being the reason for the prominent anti-depressant qualities. In addition, a 2015 study on humans and rats found that high levels of Anandamide can lead to elevated moods and lower fear levels.
● Anti-inflammatory effects– The profound anti-inflammatory properties of CBD have also been shown to have a deep connection the promotion of Anandamide and another cannabinoid, 2-Arachidonoylglycerol. These two indigenous cannabinoids influence the immune system to quell hyperactivity and superfluous inflammation.
● Aids in Homeostasis and Neurogenesis– As we discussed above, Anandamide is produced by our body naturally to enhance homeostasis and in particular Neurogenesis. The production of new cells during this process aids in a variety of cognitive processes such as memory and learning. Several studies have related how CBD’s enhancing of Anandamide assist the indigenous cannabinoid in the important process of neurogenesis.
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